Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 19, Issue 2, Pages 201-208Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.200800483
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Funding
- Australian Research Council [LP0560749, DP0663290, DP0662816, DP0343840]
- ARC Federation Fellowship [FF0241218]
- International Science Linkages program [CG060027]
- OzNano2Life postdoctoral fellowships
- Monash fellowships
- Victorian State Government
- Australian Research Council [DP0663290, DP0662816, LP0560749, DP0343840, FF0241218] Funding Source: Australian Research Council
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The development of nanostructured microcapsules based on a biomimetic lipid bilayer membrane (BLM) coating of poly(sodium styrenesulfonate) (PSS)/poly(allylamine hydrochloride) (PAH) polyelectrolyte hollow microcapsules Is reported. A novel engineered ion channel, gramicidin (bis-gA), incorporated Into the lipid membrane coating provides a functional capability to control transport across the microcapsule wall. The microcapsules provide transport and permeation for drug-analog neutral species, as well as positively and negatively charged ionic species. This controlled transport can be tuned for selective release biomimetically by controlling the gating of incorporated bis-gA ion channels. This system provides a platform for the creation of smart biomimetic delivery vessels for the effective and selective therapeutic delivery and targeting of drugs.
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