Journal
NATURE REVIEWS IMMUNOLOGY
Volume 10, Issue 4, Pages 236-247Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2729
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Funding
- US National Institutes of Health [R01AI068056, R01AI061511]
- University of Rochester
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B cells are essential for humoral immunity, but the role that they have in regulating CD4(+) T cell responses remains controversial. However, new data showing that the transient depletion of B cells potently influences the induction, maintenance and reactivation of CD4(+) T cells, with the recent identification of antibody-independent functions of B cells, have reinvigorated interest in the many roles of B cells in both infectious and autoimmune diseases. In this Review, we discuss recent data showing how effector and regulatory B cells modulate CD4(+) T cell responses to pathogens and autoantigens.
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