Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 74, Issue -, Pages 95-103Publisher
ELSEVIER
DOI: 10.1016/j.addr.2014.01.003
Keywords
3D constructs; Human-tissue model; Layer-by-layer assembly; Vasculature; Extracellular matrix; Nano-films
Categories
Funding
- PRESTO-JST
- Industrial Technology Research Grant Program from NEDO of Japan [06B44017a]
- MEXT of Japan [21106514]
- Noguchi Institute Fund
- JSPS [LR026]
- Grants-in-Aid for Scientific Research [21106514] Funding Source: KAKEN
Ask authors/readers for more resources
Three-dimensional (3D) tissue constructs consisting of human cells have opened a new avenue for tissue engineering, pharmaceutical and pathophysiological applications, and have great potential to estimate the dynamic pharmacological effects of drug candidates, metastasis processes of cancer cells, and toxicity expression of nano-materials, as a 3D-human tissue model instead of in vivo animal experiments. However, most 3D-cellular constructs are a cell spheroid, which is a heterogeneous aggregation, and thus the reconstruction of the delicate and precise 3D-location of multiple types of cells is almost impossible. In recent years, various novel technologies to develop complex 3D-human tissues including blood and lymph capillary networks have demonstrated that physiological human tissue responses can be replicated in the nano/micro-meter ranges. Here, we provide a brief overview on current 3D-tissue fabrication technologies and their biomedical applications. 3D-human tissue models will be a powerful technique for pathophysiological applications. (C) 2014 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available