Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 69, Issue -, Pages 42-51Publisher
ELSEVIER
DOI: 10.1016/j.addr.2014.01.001
Keywords
Three-dimensional cell culture; Co-culture; Microenvironment; Tissue architecture; Signaling pathway; Breast cancer
Categories
Funding
- National Cancer Institute [R37CA064786, U01CA143233, U54CA112970, U01CA169538]
- U.S. Department of Defense [W81XWH0810736]
- U.S. Department of Energy, Office of Biological and Environmental Research [DE-ACO205CH1123]
- Breast Cancer Research Foundation
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The recent cataloging of the genomic aberrations in breast cancer has revealed the diversity and complexity of the disease at the genetic level. To unravel the functional consequences of specific repertoires of mutations and copy number changes on signaling pathways in breast cancer, it is crucial to develop model systems that truly recapitulate the disease. Here we discuss the three-dimensional culture models currently being used or recently developed for the study of normal mammary epithelial cells and breast cancer, including primary tumors and dormancy. We discuss the insights gained from these models in regards to cell signaling and potential therapeutic strategies, and the challenges that need to be met for the generation of heterorypic breast cancer model systems that are amenable for high-throughput approaches. Published by Elsevier B.V.
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