Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 79-80, Issue -, Pages 19-29Publisher
ELSEVIER
DOI: 10.1016/j.addr.2014.06.002
Keywords
Angiogenesis; Hydrogel; Tumor modeling; Three-dimensional cell culture; ECM remodeling
Categories
Funding
- National Cancer Institute Physical Sciences-Oncology Network [U54CA143868]
Ask authors/readers for more resources
A growing number of failing clinical trials for cancer therapy are substantiating the need to upgrade the current practice in culturing tumor cells and modeling tumor angiogenesis in vitro. Many attempts have been made to engineer vasculature in vitro by utilizing hydrogels, but the application of these tools in simulating in vivo tumor angiogenesis is still very new. In this review, we explore current use of hydrogels and their design parameters to engineer vasculogenesis and angiogenesis and to evaluate the angiogenic capability of cancerous cells and tissues. By coupling these hydrogels with other technologies such as lithography and three-dimensional printing, one can create an advanced microvessel model as microfluidic channels to more accurately capture the native angiogenesis process. (C) 2014 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available