Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 69, Issue -, Pages 52-66Publisher
ELSEVIER
DOI: 10.1016/j.addr.2013.11.010
Keywords
Microfluidics; Cancer models; Pre-clinical drug assessment; Cell culturing devices; Extracellular matrix; Microfabricated model systems; Tumor microenvironment; Cell adhesion-mediated drug resistance; Combinatorial screening platforms; Body-on-a-chip
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Funding
- Swiss National Science foundation (SNF) [PA00P3_142120/1]
- Commonwealth of Pennsylvania
- NCI/NIH [CA113451, CA06927]
- Swiss Competence Center for Materials Science and Technology (CCMX)
- Swiss National Science Foundation (SNF) [PA00P3_142120] Funding Source: Swiss National Science Foundation (SNF)
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Cancer is one of the most common causes of death worldwide. Consequently, important resources are directed towards bettering treatments and outcomes. Cancer is difficult to treat due to its heterogeneity, plasticity and frequent drug resistance. New treatment strategies should strive for personalized approaches. These should target neoplastic and/or activated microenvironmental heterogeneity and plasticity without triggering resistance and spare host cells. In this review, the putative use of increasingly physiologically relevant microfabricated cell-culturing systems intended for drug development is discussed. There are two main reasons for the use of miniaturized systems. First, scaling down model size allows for high control of microenvironmental cues enabling more predictive outcomes. Second, miniaturization reduces reagent consumption, thus facilitating combinatorial approaches with little effort and enables the application of scarce materials, such as patient-derived samples. This review aims to give an overview of the state-of-the-art of such systems while predicting their application in cancer drug development. (C) 2013 Elsevier B.V. All rights reserved.
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