Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 65, Issue 11-12, Pages 1600-1610Publisher
ELSEVIER
DOI: 10.1016/j.addr.2013.07.016
Keywords
Acoustofluidics; Ultrasonic radiation forces; Microfluidics; Lab-on-chip; Acoustic streaming
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Funding
- EPSRC [EP/G012075/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/G012075/1] Funding Source: researchfish
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Ultrasonic fields are able to exert forces on cells and other micron-scale particles, including microbubbles. The technology is compatible with existing lab-on-chip techniques and is complementary to many alternative manipulation approaches due to its ability to handle many cells simultaneously over extended length scales. This paper provides an overview of the physical principles underlying ultrasonic manipulation, discusses the biological effects relevant to its use with cells, and describes emerging applications that are of interest in the field of drug development and delivery on-chip. (C) 2013 Elsevier B.V. All rights reserved.
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