Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 65, Issue 4, Pages 570-580Publisher
ELSEVIER
DOI: 10.1016/j.addr.2012.07.003
Keywords
Antimicrobial surfaces; Titania; TiO2; Doped TiO2; Doped titania; Functional materials and functional surfaces; Photodynamic therapy; Photosensitiser dyes; Photocatalysis of microbes
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Funding
- MRC [G0902208] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [955465] Funding Source: researchfish
- Medical Research Council [G0902208] Funding Source: researchfish
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This review focuses on the development of light activated antimicrobial surfaces. These surfaces kill microbes by the action of light and have potential applications in domestic and healthcare settings. The inspiration for the new self-cleaning surfaces originates from photodynamic therapy where light is used to locate and destroy tumours. The first generation photosensitiser molecules, based on a porphyrin ring structure, could be considered as bioinspired and chemically related to chlorophyll. The review looks at developments of both soft polymeric surfaces with either surface bound or impregnated photosensitiser molecules; and hard inorganic surfaces such as modified titanium dioxide. The bacterial kill mechanisms are looked into with both surface types showing primary microbial kill through a radical induced pathway. The hard inorganic surfaces also show low bacterial adherence by means of a light activated photo-wetting of the surfaces meaning that they are Easy Clean and wash off microbes uniformly. (C) 2012 Elsevier B.V. All rights reserved.
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