Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 64, Issue -, Pages 316-326Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2012.09.008
Keywords
Long-circulating nanoparticles; Biodegradable polymers; Polyethylene glycol; Hydrophilic coating; Reduced liver accumulation; Intravenous drug administration
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Funding
- French Foreign Affairs Ministry
- NIH [GM26698]
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Injectable blood persistent particulate carriers have important therapeutic application in site-specific drug delivery or medical imaging. However, injected particles are generally eliminated by the reticuloendothelial system within minutes after administration and accumulate in the liver and spleen. To obtain a coating that might prevent opsonization and subsequent recognition by the macrophages, sterically stabilized nanospheres were developed using amphiphilic diblock or multiblock copolymers. The nanospheres are composed of a hydrophilic polyethylene glycol coating and a biodegradable core in which various drugs were encapsulated. Hydrophobic drugs, such as lidocaine, were entrapped up to 45 wt% and the release kinetics were governed by the polymer physico-chemical characteristics. Plasma protein adsorption was drastically reduced on PEG-coated particles compared to non-coated ones. Relative protein amounts were time-dependent. The nanospheres exhibited increased blood circulation times and reduced liver accumulation, depending on the coating polyethylene glycol molecular weight and surface density. They could be freeze-dried and redispersed in aqueous solutions and possess good shelf stability. It may be possible to tailor optimal polymers for given therapeutic applications. (C) 2012 Published by Elsevier B.V.
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