Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 64, Issue 12, Pages 1177-1188Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2012.03.002
Keywords
Wound healing; Tendon repair; Diabetes; Osteoporosis; S-nitrosothiol; N-diazeniumdiolate; Organic nitrate; Collagen; Osteoblast; Osteoclast
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Funding
- National Institutes of Health [EB000708]
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Non-invasive treatment of injuries and disorders affecting bone and connective tissue remains a significant challenge facing the medical community. A treatment route that has recently been proposed is nitric oxide (NO) therapy. Nitric oxide plays several important roles in physiology with many conditions lacking adequate levels of NO. As NO is a radical, localized delivery via NO donors is essential to promoting biological activity. Herein, we review current literature related to therapeutic NO delivery in the treatment of bone, skin and tendon repair. (C) 2012 Elsevier B.V. All rights reserved.
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