Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 64, Issue 11, Pages 1021-1030Publisher
ELSEVIER
DOI: 10.1016/j.addr.2012.01.003
Keywords
Top-down; Trigger-release; Microfluidic; Photolithography; PRINT
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Funding
- National Institutes of Health Grants [1R01EB009565-02, NIHR01, U54CA119373, 1DP10D006432-01]
- University Cancer Research Fund at the University of North Carolina at Chapel Hill
- William R. Kenan Professorship at the University of North Carolina at Chapel Hill
- Liquidia Technologies
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The ability to engineer particles has the potential to shift the paradigm in the creation of new medicines and diagnostics. Complete control over particle characteristics, such as size, shape, mechanical property, and surface chemistry, can enable rapid translation and facilitate the US Food and Drug Administration (FDA) approval of particle technologies for the treatment of cancer, infectious diseases, diabetes, and a host of other major illnesses. The incorporation of natural and artificial external stimuli to trigger the release of drugs enables exquisite control over the release profiles of drugs in a given environment. In this article, we examine several readily scalable top-down methods for the fabrication of shape-specific particles that utilize stimuli-responsive biomaterials for controlled drug delivery. Special attention is given to Particle Replication In Nonwetting Templates (PRINT (R)) technology and the application of novel triggered-release synthetic and natural polymers. (c) 2012 Elsevier B.V. All rights reserved.
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