Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 64, Issue 2, Pages 200-216Publisher
ELSEVIER
DOI: 10.1016/j.addr.2011.08.006
Keywords
Gold; Nanoparticles; Monolayer; Delivery; Organic monolayer; Biomolecule coated; DNA; Drug delivery; Protein; Small molecule
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Funding
- NIH [GM077173]
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Gold nanoparticles (AuNPs) provide attractive vehicles for delivery of drugs, genetic materials, proteins, and small molecules. AuNPs feature low core toxicity coupled with the ability to parametrically control particle size and surface properties. In this review, we focus on engineering of the AuNP surface monolayer, highlighting recent advances in tuning monolayer structures for efficient delivery of drugs and biomolecules. This review covers two broad categories of particle functionalization, organic monolayers and biomolecule coatings, and discusses their applications in drug, DNA/RNA, protein and small molecule delivery. (c) 2011 Elsevier B.V. All rights reserved.
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