Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 64, Issue 12, Pages 1129-1141Publisher
ELSEVIER
DOI: 10.1016/j.addr.2012.04.008
Keywords
Bone tissue engineering; Nanofibrous scaffold; Osteogenic microenvironment; Bioactive agent delivery; Stem cell delivery
Categories
Funding
- Whitaker Foundation [RG-99-0137]
- NIH [DE014755, DE015384, GM075840, DE017689, DE022327]
- DOD [W81XWH-12-2-0008]
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Biodegradable nanofibers are important scaffolding materials for bone regeneration. In this paper, the basic concepts and recent advances of self-assembly, electrospinning and thermally induced phase separation techniques that are widely used to generate nanofibrous scaffolds are reviewed. In addition, surface functionalization and bioactive factor delivery within these nanofibrous scaffolds to enhance bone regeneration are also discussed. Moreover, recent progresses in applying these nanofiber-based scaffolds to deliver stem cells for bone regeneration are presented. Along with the significant advances, challenges and obstacles in the field as well as the future perspective are discussed. (C) 2012 Elsevier B.V. All rights reserved.
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