Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 64, Issue 7, Pages 590-597Publisher
ELSEVIER
DOI: 10.1016/j.addr.2012.01.004
Keywords
Convection-enhanced delivery; CED; Intrathecal; Intranasal; Glioma; Glioblastoma; Liposome; Chemotherapy
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Funding
- NINDS NIH HHS [R21 NS065819] Funding Source: Medline
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The majority of newly diagnosed brain tumors are treated with surgery, radiation, and the chemotherapeutic temozolomide. Development of additional therapeutics to improve treatment outcomes is complicated by the blood-brain barrier (BBB), which acts to protect healthy tissue from chemical insults. The high pressure found within brain tumors adds a challenge to local delivery of therapy by limiting the distribution of bolus injections. Here we discuss various drug delivery strategies, including convection-enhanced delivery, intranasal delivery, and intrathecal delivery, as well as pharmacological strategies for improving therapeutic efficacy, such as blood-brain barrier disruption. (c) 2012 Elsevier B.V. All rights reserved.
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