Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 64, Issue 12, Pages 1257-1276Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2012.05.006
Keywords
Growth factor delivery; Bone regeneration; Biomaterials; Tissue engineering; Spatial regulation; Temporal regulation; Bio-inspired
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Funding
- Einstein Foundation Berlin through the Charite - Universitatsmedizin Berlin, Berlin-Brandenburg School for Regenerative Therapies [GSC 203]
- Nachwuchsakademie Medizintechnik [DFG-ME 4083/1-1]
- NIH [R37 DE013033]
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Complications in treatment of large bone defects using bone grafting still remain. Our understanding of the endogenous bone regeneration cascade has inspired the exploration of a wide variety of growth factors (GFs) in an effort to mimic the natural signaling that controls bone healing. Biomaterial-based delivery of single exogenous GFs has shown therapeutic efficacy, and this likely relates to its ability to recruit and promote replication of cells involved in tissue development and the healing process. However, as the natural bone healing cascade involves the action of multiple factors, each acting in a specific spatiotemporal pattern, strategies aiming to mimic the critical aspects of this process will likely benefit from the usage of multiple therapeutic agents. This article reviews the current status of approaches to deliver single GFs, as well as ongoing efforts to develop sophisticated delivery platforms to deliver multiple lineage-directing morphogens (multiple GFs) during bone healing. (C) 2012 Elsevier B.V. All rights reserved.
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