Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 64, Issue 12, Pages 1111-1122Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2012.03.016
Keywords
Silk-fibroin; Musculoskeletal diseases; Drug delivery; Implant; Injectable drug delivery systems
Categories
Funding
- NIH
- NSF
- AFOSR
- DARPA
- CCMX
- Deutsche Forschungsgemeinschaft [SFB 630]
- German Alexander von Humboldt Foundation
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Silk fibroin (SF) is a biopolymer with distinguishing features from many other bio-as well as synthetic polymers. From a biomechanical and drug delivery perspective, SF combines remarkable versatility for scaffolding (solid implants, hydrogels, threads, solutions), with advanced mechanical properties and good stabilization and controlled delivery of entrapped protein and small molecule drugs, respectively. It is this combination of mechanical and pharmaceutical features which renders SF so exciting for biomedical applications. This pattern along with the versatility of this biopolymer has been translated into progress for musculoskeletal applications. We review the use and potential of silk fibroin for systemic and localized delivery of therapeutics in diseases affecting the musculoskeletal system. We also present future directions for this biopolymer as well as the necessary research and development steps for their achievement. (c) 2012 Elsevier B.V. All rights reserved.
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