Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 64, Issue 14, Pages 1639-1649Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2012.05.002
Keywords
Multidrug delivery; Microvalve manifold; Liquid flow control; MEMS; Implantable drug pump; Wearable drug pump; Power transfer; Piezoelectric
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Funding
- University of Michigan, Department of Internal Medicine, Division of Anesthesiology
- Michigan Institute for Clinical and Health Research (MICHR)
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This paper describes a valve-regulated architecture, for intrathecal, insulin and other drug delivery systems, that offers high performance and volume efficiency through the use of micromachined components. Multidrug protocols can be accommodated by using a valve manifold to modulate and mix drug flows from individual reservoirs. A piezoelectrically-actuated silicon microvalve with embedded pressure sensors is used to regulate dosing by throttling flow from a mechanically-pressurized reservoir. A preliminary prototype system is demonstrated with two reservoirs, pressure sensors, and a control circuit board within a 130 cm(3) metal casing. Different control modes of the programmable system have been evaluated to mimic clinical applications. Bolus and continuous flow deliveries have been demonstrated. A wide range of delivery rates can be achieved by adjusting the parameters of the manifold valves or reservoir springs. The capability to compensate for changes in delivery pressure has been experimentally verified. The pressure profiles can also be used to detect catheter occlusions and disconnects. The benefits of this architecture compared with alternative options are reviewed. (C) 2012 Elsevier B.V. All rights reserved.
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