Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 63, Issue 4-5, Pages 269-276Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2011.01.004
Keywords
Substrate stiffness; Elasticity; Biomechanics; Stem cells; Cancer biology; Mechanobiology; Biomaterials
Categories
Funding
- Canadian Institutes of Health Research [MOP-102721]
- Natural Science and Engineering Research Council of Canada (NSERC) [RGPIN 327627-06]
- Heart and Stroke Foundation of Ontario [NA6654]
- Canada Research Chair in Mechanobiology
- NSERC
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Diseased tissues are noted for their compromised mechanical properties, which contribute to organ failure; regeneration entails restoration of tissue structure and thereby functions. Thus, the physical signature of a tissue is closely associated with its biological function. In this review, we consider a mechanics-centric view of disease and regeneration by drawing parallels between in vivo tissue-level observations and corroborative cellular evidence in vitro to demonstrate the importance of the mechanical stiffness of the extracellular matrix in these processes. This is not intended to devalue the importance of biochemical signaling: in fact, as we discuss, many mechanical stiffness-driven processes not only require cooperation with biochemical cues, but they ultimately converge at common signaling cascades to influence cell and tissue function in an integrative manner. The study of how physical and biochemical signals collectively modulate cell function not only brings forth a more holistic understanding of cell (patho)biology, but it also creates opportunities to control material properties to improve culture platforms for research and drug screening and aid in the rationale design of biomaterials for molecular therapy and tissue engineering applications. (C) 2011 Elsevier B.V. All rights reserved.
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