Microgels and microcapsules in peptide and protein drug delivery

The present review focuses on the interaction of microgels and microcapsules with biological macromolecules, particularly peptides and proteins, as well as drug delivery applications of such systems. Results from recent studies on factors affecting peptide/protein binding to, and release from, microgels and related systems are discussed, including effects of network properties, as well as protein aggregation, peptide length, hydrophobicity and charge (distributions), secondary structure, and cyclization. Effects of ambient conditions (pH, ionic strength, temperature, etc.) are also discussed, all with focus on factors of importance for the performance of microgel and microcapsule delivery systems for biomacromolecular drugs. (C) 2011 Elsevier B.V. All rights reserved.