Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 63, Issue 9, Pages 772-788Publisher
ELSEVIER
DOI: 10.1016/j.addr.2011.03.013
Keywords
Layer-by-layer; Self-assembly; Polyelectrolyte capsule; Magnetic resonance imaging; Paramagnetic; Superparamagnetic; Gadolinium; Iron oxide; Drug delivery; Molecular imaging
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Funding
- Program for New Century Excellent Talents in University [NCET-06-0781]
- Ministry of Education of China [20090181110068]
- Distinguished Young Scholars Project of Sichuan Province [06ZQ026-007]
- National Natural Science Foundation of China [30570514, 20974065, 50603015, 50830107]
- Sichuan University (Ministry of Education)
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Layer-by-layer (LbL) self-assembled polyelectrolyte capsules have demonstrated their unique advantages and capability in drug delivery applications. These ordered micro/nano-structures are also promising candidates as imaging contrast agents for diagnostic and theranostic applications. Magnetic resonance imaging (MRI), one of the most powerful clinical imaging modalities, is moving forward to the molecular imaging field and requires the availability of advanced imaging probes. In this review, we are focusing on the design of MRI visible LbL capsules, which incorporate either paramagnetic metal-ligand complexes or superparamagnetic iron oxide (SPIO) nanoparticles. The design criteria cover the topics of probe sensitivity, biosafety, long-circulation property, targeting ligand decoration, and drug loading strategies. Examples of MRI visible LbL capsules with paramagnetic or superparamagnetic moieties were given and discussed. This carrier platform can also be chosen for other imaging modalities. (C) 2011 Elsevier B.V. All rights reserved.
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