Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 63, Issue 12, Pages 988-999Publisher
ELSEVIER
DOI: 10.1016/j.addr.2011.06.018
Keywords
Complement activation; Surface plasmon resonance; Self-assembled monolayer; Polymer coating; Nonspecific protein adsorption; The classical pathway; The alternative pathway
Categories
Funding
- Ministry of Education, Culture, Sports. Science, and Technology (MEXT) of Japan [21240051]
- Kyoto City Collaboration of Regional Entities for the Advancement of Technological Excellence
- JST, Japan
- Grants-in-Aid for Scientific Research [21240051] Funding Source: KAKEN
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When artificial materials come into contact with blood, various biological responses are induced. For successful development of biomaterials used in biomedical devices that will be exposed to blood, understanding and control of these interactions are essential. Surface plasmon resonance (SPR) spectroscopy is one of the surface-sensitive optical methods to monitor biological interactions. SPR enables real-time and in situ analysis of interfacial events associated with biomaterials research. In this review, we describe an SPR biosensor and its application to monitor complement activation onto biomaterials surface. We also discuss the effect of surface properties of the material on complement activation. (C) 2011 Elsevier B.V. All rights reserved.
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