Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 63, Issue 9, Pages 789-808Publisher
ELSEVIER
DOI: 10.1016/j.addr.2011.03.008
Keywords
Hyperthermia; Hyperthermia-based therapy; Hyperthermia-based controlled drug delivery; Core-shell magnetic nanoparticles; Theranostics
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Funding
- Louisiana Board of Regents [LEQSF (2008-10)-ENH-TR-07]
- NIH [1RO1CA142-01A1, P20RR016456]
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Previous attempts to review the literature on magnetic nanomaterials for hyperthermia-based therapy focused primarily on magnetic fluid hyperthermia (MFH) using mono metallic/metal oxide nanoparticles. The term hyperthermia in the literature was also confined only to include use of heat for therapeutic applications. Recently, there have been a number of publications demonstrating magnetic nanoparticle-based hyperthermia to generate local heat resulting in the release of drugs either bound to the magnetic nanoparticle or encapsulated within polymeric matrices. In this review article, we present a case for broadening the meaning of the term hyperthermia by including thermotherapy as well as magnetically modulated controlled drug delivery. We provide a classification for controlled drug delivery using hyperthermia: Hyperthermia-based controlled drug delivery through bond breaking (DBB) and hyperthermia-based controlled drug delivery through enhanced permeability (DEP). The review also covers, for the first time, core-shell type magnetic nanomaterials, especially nanoshells prepared using layer-by-layer self-assembly, for the application of hyperthermia-based therapy and controlled drug delivery. The highlight of the review article is to portray potential opportunities for the combination of hyperthermia-based therapy and controlled drug release paradigms -towards successful application in personalized medicine. (C) 2011 Elsevier B.V. All rights reserved.
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