Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 62, Issue 1, Pages 100-117Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2009.11.026
Keywords
Chitosan; Ocular; Ophthalmics; Drug delivery; Gene delivery; Hyaluronan; Nanocapsules; Nanoparticles; Nanostructures; Emulsions
Categories
Ask authors/readers for more resources
Nanoscience and nanotechnology has caused important breakthroughs in different therapeutic areas. In particular, the application of nanotechnology in ophthalmology has led to the development of novel strategies for the treatment of ocular disorders. Indeed, the association of an active molecule to a nanocarrier allows the molecule to intimately interact with specific ocular structures, to overcome ocular barriers and to prolong its residence in the target tissue. Over the last decade, our group has designed and developed a delivery platform based on the polysaccharide chitosan, which suits the requirements of the topical ocular route. These nanosystems have been specifically adapted for the delivery of hydrophilic and lipophilic drugs and also polynucleotides onto the eye surface. The results collected up until now suggest the potential of this delivery platform and the subsequent need of a full preclinical evaluation in order to satisfy the specific regulatory demands of this mode of administration. (C) 2009 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available