Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 62, Issue 6, Pages 606-616Publisher
ELSEVIER
DOI: 10.1016/j.addr.2010.03.004
Keywords
DNA; Nanomedicine; Polymer topologies; Nano-assembly; DNA nanostructures
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Nanomedicine, the application of nanotechnology to medicine, encompasses a broad spectrum of fields including molecular detection, diagnostics, drug delivery, gene regulation and protein production. In recent decades, DNA has received considerable attention for its functionality and versatility, allowing it to help bridge the gap between materials science and biological systems. The use of DNA as a structural nanoscale material has opened a new avenue towards the rational design of DNA nanostructures with different polymeric topologies. These topologies, in turn, possess unique characteristics that translate to specific therapeutic and diagnostic strategies within nanomedicine. (C) 2010 Elsevier By. All rights reserved.
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