Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 62, Issue 7-8, Pages 683-698Publisher
ELSEVIER
DOI: 10.1016/j.addr.2010.01.002
Keywords
Gene-and-cell therapy; Genetic engineering; Regenerative medicine; Tissue-specific genes; Tissue engineering; Stem cells
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Funding
- NIH [RO3 AR057143, R01 AR056694, R43 AR057587]
- Telemedicine and Advanced Technology Research Center (TATRC)
- U.S. Army Medical Research and Materiel Command
- Israeli Ministry of Science
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Regenerative medicine appears to take as its patron, the Titan Prometheus, whose liver was able to regenerate daily, as the field attempts to restore lost, damaged, or aging cells and tissues. The tremendous technological progress achieved during the last decade in gene transfer methods and imaging techniques, as well as recent increases in our knowledge of cell biology, have opened new horizons in the field of regenerative medicine. Genetically engineered cells are a tool for tissue engineering and regenerative medicine, albeit a tool whose development is fraught with difficulties. Gene-and-cell therapy offers solutions to severe problems faced by modern medicine, but several impediments obstruct the path of such treatments as they move from the laboratory toward the clinical setting. In this review we provide an overview of recent advances in the gene-and-cell therapy approach and discuss the main hurdles and bottlenecks of this approach on its path to clinical trials and prospective clinical practice. (C) 2010 Elsevier B.V. All rights reserved.
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