Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 62, Issue 9-10, Pages 967-978Publisher
ELSEVIER
DOI: 10.1016/j.addr.2010.05.005
Keywords
Circadian; Clock genes; Chronodisruption; Rhythmicity; Bmal1; Per1; Cry; Clock; Melatonin
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Funding
- Government of Education, Science and Research of Murcia [BIO/FFA 07/01-0004]
- The Spanish Ministry of Education and Science [AGL2008-01655/ALI, BFU2007-60658/BFI]
- The Institute of Health Carlos III [RD06/0013/0019]
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The present review starts from the classical physiological and nutritional studies related with food intake control, digestion, transport and absorption of nutrients. It continues with studies related with the metabolism of adipose tissue, and finish with modern experiments in genetics and molecular biology - all from a fresh, chronobiological point of view. Obesity will be explained as a fault in the circadian system, as pathology associated with chronodisruption. The main gaps in chronobiological research related to obesity will be also identified and chronobiological-based therapies will be proposed in order to allow the resetting of the circadian rhythm among obese subjects. (C) 2010 Elsevier B.V. All rights reserved.
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