Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 61, Issue 6, Pages 428-437Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2009.03.009
Keywords
Nanoparticles; Protein binding; Immunology; Biodistribution; Biocompatibility
Categories
Funding
- National Cancer Institute, National Institutes of Health [N01 -CO-12400]
Ask authors/readers for more resources
Proteins bind the surfaces of nanoparticles, and biological materials in general, immediately upon introduction of the materials into a physiological environment. The further biological response of the body is influenced by the nanoparticle-protein complex. The nanoparticle's composition and surface chemistry dictate the extent and specificity of protein binding. Protein binding is one of the key elements that affects biodistribution of the nanoparticles throughout the body. Here we review recent research on nanoparticle physicochemical properties important for protein binding, techniques for isolation and identification of nanoparticle-bound proteins, and how these proteins can influence particle biodistribution and biocompatibility. Understanding the nanoparticle-protein complex is necessary for control and manipulation of protein binding. and allows for improved engineering of nanoparticles with favorable bioavailability and biodistribution. (C) 2009 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available