Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 61, Issue 15, Pages 1391-1401Publisher
ELSEVIER
DOI: 10.1016/j.addr.2009.09.002
Keywords
Responsive hydrogels; Intelligent therapeutics; Micro- and nano-electromechanical systems; Biosensors; Controlled drug delivery; Tissue engineering
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Funding
- National Science Foundation
- National Institutes of Health [EB-000246]
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Advances in medical treatments of a wide variety of pathophysiological conditions require the development of better therapeutic agents, as well as a combination of the required therapeutic agents with device-integrated biomaterials that can serve as sensors and carriers. Combination of micro- and nano-fabricated systems with intelligent biomaterials that have the ability to sense and respond is a promising avenue for the development of better diagnostic and therapeutic medical systems. Micro- and nano-electromechanical systems (MEMs and NEMs) are now becoming a family of potentially powerful new technologies for drug delivery, diagnostic tools, and tissue engineering. Improvements in micro- and nano-fabrication technologies have enhanced the ability to create better performing therapeutic systems for numerous pathophysiological applications. More importantly, MEMS- and NEMS-based tissue regeneration scaffolds, biosensors, and drug delivery devices provide new opportunities to mimic the natural intelligence and response of biological systems. Published by Elsevier B.V.
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