Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 61, Issue 14, Pages 1283-1298Publisher
ELSEVIER
DOI: 10.1016/j.addr.2009.07.015
Keywords
Mitochondria; Energy-redox axis; Lipoic acid; Thiol/disulfide exchange; Alzheimer's disease; Aging
Categories
Funding
- NIH [RO1-AG16718, AA016911]
- TRDRP [16RT-0186]
- Office of the Provost at the University of Southern California
- DH
Ask authors/readers for more resources
Decrease in mitochondrial energy-transducing capacity is a feature of the aging process that accompanies redox alterations, such as increased generation of mitochondrial oxidants, altered GSH status, and increased protein oxidation. The decrease in mitochondrial energy-transducing capacity and altered redox status should be viewed as a concerted process that embodies the mitochondrial energy-redox axis and is linked through various mechanisms including: (a) an inter-convertible reducing equivalents pool (i.e., NAD(P)(+)/NAD(P)H) and (b) redox-mediated protein post-translational modifications involved in energy metabolism. The energy-redox axis provides the rationale for therapeutic approaches targeted to each or both component(s) of the axis that effectively preserves or improve mitochondrial function and that have implications for aging and age-related neurodegenerative disorders. (C) 2009 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available