Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 61, Issue 1, Pages 66-72Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2008.08.008
Keywords
ERAD; Ubiquitin; Proteasome; Endosome; Lysosome; N-glycosylation; Disulfide bond
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Funding
- NEDO International Joint Research [18201041]
- Japanese Society for the Promotion of Science USPS
- Ministry of Education, Culture, Sports, Science and Technology [19791361]
- Grants-in-Aid for Scientific Research [19791361] Funding Source: KAKEN
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Human ATP-binding cassette (ABC) transporter ABCG2 (BCRP/MXR/ABCP) is a plasma membrane protein carrying intra- and inter-molecular disulfide bonds and an Winked glycan. Both disulfide bond formation and N-glycosylation are critical check points determining the stability and degradation fate of ABCG2 protein in the endoplasmic reticulum (ER). Misfolded ABCG2 protein without those post-translational modifications is removed from the ER by retrotranslocation to the cytosol compartment, ubiquitination by ubiquitin ligase, and finally degradation by proteasomes. Certain non-synonymous SNP variants of ABCG2 undergo such ER-associated degradation (ERAD). (C) 2008 Elsevier B.V. All rights reserved.
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