Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 60, Issue 11, Pages 1278-1288Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2008.03.012
Keywords
mesoporous silica nanoparticles (MSN); intracellular drug delivery; gene transfection; controlled release; morphology control; nanoparticle endocytosis; biocompatibility
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In this review, we highlight the recent research developments of a series of surface-functionalized mesoporous silica nanoparticle (MSN) materials as efficient drug delivery carriers. The synthesis of this type of MSN materials is described along with the current methods for controlling the structural properties and chemical functionalization for biotechnological and biomedical applications. We summarized the advantages of using MSN for several drug delivery applications. The recent investigations of the biocompatibility of MSN in vitro are discussed. We also describe the exciting progress on using MSN to penetrate various cell membranes in animal and plant cells. The novel concept of gatekeeping is introduced and applied to the design of a variety of stimuli-responsive nanodevices. We envision that these MSN-based systems have a great potential for a variety of drug delivery applications, such as the site-specific delivery and intracellular controlled release of drugs, genes, and other therapeutic agents. Published by Elsevier B.V.
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