Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 60, Issue 11, Pages 1241-1251Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2008.03.014
Keywords
iron oxide; magnetic narroparticles; peptide targeting; small molecule targeting; molecular imaging; cancer; atherosclerosis; theranostic
Categories
Funding
- NCI NIH HHS [U54 CA126515, U54-CA126515, U54 CA126515-020002, U54-CA119349, U54 CA126515-010002, U54 CA119349] Funding Source: Medline
- NHLBI NIH HHS [U01-HL080731, U01 HL080731-01, U01 HL080731, U01 HL080731-03, U01 HL080731-04, U01 HL080731-02] Funding Source: Medline
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Magnetic nanoparticles have become important tools for the imaging of prevalent diseases, such as cancer, atherosclerosis, diabetes, and others. While first generation nanoparticles were fairly nonspecific, newer generations have been targeted to specific cell types and molecular targets via affinity ligands. Commonly, these ligands emerge from phage or small molecule screens, or are based on antibodies or aptamers. Secondary reporters and combined therapeutic molecules have further opened potential clinical applications of these materials. This review summarizes some of the recent biomedical applications of these newer magnetic nanomaterials. (c) 2008 Elsevier B.V. All rights reserved.
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