Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 60, Issue 2, Pages 199-214Publisher
ELSEVIER
DOI: 10.1016/j.addr.2007.08.036
Keywords
embryonic stem cells; biomaterials; microenvironment; differentiation; self-renewal; biomimetic
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Funding
- NIBIB NIH HHS [R01 EB005517-01, R01 EB005517, R01 EB005517-03, R01 EB005517-04, R01 EB005517-02] Funding Source: Medline
- NIDCR NIH HHS [R01 DE016887-02, R01 DE016887, R01 DE016887-01A1, R01 DE016887-03S1, R01 DE016887-03] Funding Source: Medline
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The extracellular microenvironment plays a significant role in controlling cellular behavior. Identification of appropriate biomaterials that support cellular attachment, proliferation and, most importantly in the case of human embryonic stem cells, lineage-specific differentiation is critical for tissue engineering and cellular therapy. In addition to growth factors and morphogenetic factors known to induce lineage commitment of stem cells, a number of scaffolding materials, including synthetic and naturally-derived biomaterials, have been utilized in tissue engineering approaches to direct differentiation. This review focuses on recent emerging findings and well-characterized differentiation models of human embryonic stem cells. Additionally, we also discuss about various strategies that have been used in stem cell expansion. (c) 2007 Published by Elsevier B.V.
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