Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 60, Issue 7, Pages 841-846Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2007.12.001
Keywords
interferon; RLR; dsRNA; viral RNA; self-non-self recognition
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Non-self RNA appearing in a cell as a result of viral replication is detected by a cytoplasmic sensor called RIG-I-like receptor (RLR). RLR consists of RIG-I, MDA5, and LGP2, which are DExD/H helicases. Dornain structures of RLR for detecting non-self RNA and for relaying signals downstream have been elucidated. Different viruses produce structurally different RNA species and are sensed differentially by RLR molecules to initiate antiviral responses and subsequent antigen-specific adaptive immunity. (c) 2008 Elsevier B.V. All rights reserved.
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