Journal
ADDICTION BIOLOGY
Volume 20, Issue 3, Pages 482-489Publisher
WILEY
DOI: 10.1111/adb.12142
Keywords
Abstinence; addiction; context; extinction; mGlu5; MTEP
Categories
Funding
- National Health and Medical Research Council (NHMRC) of Australia [APP1022201]
- Australian Research Council
- NHMRC Fellowships
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We investigated the effects of extinguishing action-reward versus context-reward associations on drug-primed reinstatement, and the potential role of the metabotropic glutamate 5 receptor (mGlu5) in these different types of extinction in rats that self-administer cocaine. We observed that daily context extinction (non-reinforced exposures to the cocaine-taking context with retracted levers) was just as effective as daily lever extinction in reducing cocaine-primed reinstatement compared with passive abstinence. Additionally, systemic injections of the mGlu5 negative allosteric modulator MTEP (3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine) following each extinction session significantly impaired the ability of context extinction to reduce cocaine-primed reinstatement, without affecting reinstatement after lever extinction or passive abstinence.
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