Journal
ADDICTION BIOLOGY
Volume 20, Issue 1, Pages 38-42Publisher
WILEY-BLACKWELL
DOI: 10.1111/adb.12106
Keywords
Alcohol; alcohol dependence; alcoholism; alcohol preference; AV-411; ethanol; ibudilast; MN-166; neuroimmune; phosphodiesterase
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Funding
- National Institutes of Health from National Institute on Alcohol Abuse and Alcoholism [HHSN267200700037C, HHSN267200700038C]
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Neuroinflammatory signaling pathways in the central nervous system are of current interest as potential pharmacotherapy targets for alcohol dependence. In this study, we examined the ability of ibudilast, a non-selective phosphodiesterase inhibitor, to reduce alcohol drinking and relapse in alcohol-preferring P rats, high-alcohol drinking HAD1 rats, and in mice made dependent on alcohol through cycles of alcohol vapor exposure. When administered twice daily, ibudilast reduced alcohol drinking in rats by approximately 50% and reduced drinking by alcohol-dependent mice at doses which had no effect in non-dependent mice. These findings support the viability of ibudilast as a possible treatment for alcohol dependence.
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