Journal
ADDICTION BIOLOGY
Volume 18, Issue 1, Pages 50-53Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1369-1600.2012.00479.x
Keywords
ArchT; eNpHR3; 0; halorhodopsin; prelimbic cortex; nucleus accumbens core; reinstatement
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Funding
- National Institutes of Health [DA027055, DA015369, DA003906, T32 DA7288]
- NATIONAL INSTITUTE ON DRUG ABUSE [R37DA003906, R21DA027055, P50DA015369, R01DA012513, R01DA003906, T32DA007288] Funding Source: NIH RePORTER
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Inhibitory optogenetics was used to examine the roles of the prelimbic cortex (PL), the nucleus accumbens core (NAcore) and the PL projections to the NAcore in the reinstatement of cocaine seeking. Rats were microinjected into the PL or NAcore with an adeno-associated virus containing halorhodopsin or archaerhodopsin. After 12 days of cocaine self-administration, followed by extinction training, animals underwent reinstatement testing along with the presence/absence of optically induced inhibition via laser light. Bilateral optical inhibition of the PL, NAcore or the PL fibers in the NAcore inhibited the reinstatement of cocaine seeking.
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