Journal
ADDICTION BIOLOGY
Volume 18, Issue 5, Pages 846-850Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1369-1600.2012.00478.x
Keywords
Association; cannabis; genetics; heritability
Categories
Funding
- National Institutes of Health, Bethesda, Md [AA013326, AA014041, AA13320, AA013321, DA23668, DA12854]
- ANZ Trustees PhD scholarship in Medical Research
- NHMRC [552498]
Ask authors/readers for more resources
While initiation of cannabis use is around 40% heritable, not much is known about the underlying genetic aetiology. Here, we meta-analysed two genome-wide association studies of initiation of cannabis use with >10000 individuals. None of the genetic variants reached genome-wide significance. We also performed a gene-based association test, which also revealed no significant effects of individual genes. Finally, we estimated that only approximately 6% of the variation in cannabis initiation is due to common genetic variants. Future genetic studies using larger sample sizes and different methodologies (including sequencing) might provide more insight in the complex genetic aetiology of cannabis use.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available