Journal
ADDICTION BIOLOGY
Volume 19, Issue 1, Pages 1-4Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1369-1600.2011.00425.x
Keywords
Food-seeking behavior; galantamine; methamphetamine; methamphetamine-seeking behavior; reinstatement; self-administration
Categories
Funding
- JSPS [22248033, 20390073, 21390045]
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) [19659017, 22659213]
- Ministry of Education, Culture, Sports, Science and Technology (MEXT)
- Ministry of Health and Labour Sciences
- Ministry of Health, Labour and Welfare, Japan (MHLW)
- Japan-Korea basic scientific cooperation program (JSPS).
- Grants-in-Aid for Scientific Research [19659017, 20390073, 21390045, 22248033, 22659213, 22790233] Funding Source: KAKEN
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Methamphetamine (METH) dependence is becoming a serious socioeconomic health problem worldwide. The enhancement of the cholinergic nervous system is expected to greatly alleviate drug dependence. We investigated the effect of galantamine on the reinstatement of cue-induced METH-seeking behavior using a self-administration experiment. Treatment with galantamine (1mg/kg, p.o.) 30minutes before exposure to the cues suppressed the reinstatement of METH-seeking behavior. However, galantamine did not affect the cue-induced reinstatement of food-seeking behavior or locomotor activity. These results suggest that galantamine may be a candidate drug for treating relapses of METH-seeking behavior.
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