Journal
ADDICTION BIOLOGY
Volume 18, Issue 4, Pages 727-728Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1369-1600.2011.00316.x
Keywords
Cingulate gyrus; diffusion tensor imaging; fractional anisotropy; frontal gyrus; heroin addiction; white matter
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Funding
- National Key Basic Research and Development Program (NKBRDP) of China [2009CB522000]
- National Natural Science Foundation [30971050]
- Ministry of Education of China [20070533068]
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Previous neuroimaging studies have documented the structural damage in heroin addicts. However, little research has detailed the white matter microstructural changes in the human brain as a result of chronic heroin use and importantly, whether such changes can be recovered after short-term abstinence. Decreased fractional anisotropy values in frontal cortex were found in heroin users after 3 days of abstinence in comparison with controls. However, no significant difference was found between these heroin addicts and controls after 1-month abstinence. These results might better our understanding of the biological basis of drug addiction and provide insight into addiction treatment.
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