Journal
ADDICTION BIOLOGY
Volume 16, Issue 4, Pages 615-619Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1369-1600.2010.00304.x
Keywords
Alcoholism; C57BL/6J; clustering; ethanol dependence; extended amygdala; qPCR
Categories
Funding
- National Institutes of Health [2U01AA013517-06, 1U01AA016658-01]
- European Union [GENADDICT/FP6005166]
Ask authors/readers for more resources
Alcoholism is characterized by a progressive loss of control over ethanol intake. The purpose of this study was to identify transcriptional changes selectively associated with excessive ethanol drinking in dependent mice, as opposed to non-dependent mice maintaining a stable voluntary consumption or mice solely undergoing forced intoxication. We measured expression levels of 106 candidate genes in the extended amygdala, a key brain structure for the development of drug addiction. Cluster analysis identified 17 and 15 genes selectively induced or repressed, respectively, under conditions of excessive drinking. These genes belong to signaling pathways involved in neurotransmission and transcriptional regulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available