Journal
ACTA TROPICA
Volume 188, Issue -, Pages 16-26Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.actatropica.2018.08.032
Keywords
Hygiene hypothesis; Allergy; Autoimmune diseases; Parasite; Helminthic therapy; Microbiota therapy
Categories
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo Research Foundation) [2017/14035-1]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, The National Council for Scientific and Technological Development) [307155/2017-0]
Ask authors/readers for more resources
The hygiene hypothesis was proposed almost three decades ago. Nevertheless, its mechanism still remains with relevant controversies. Some studies defend that early exposures during childhood to microbes and parasites are key determinants to prevent allergies and autoimmune diseases; however, other studies demonstrated that these early exposures can even potentiate the clinical scenario of the diseases. Based on several studies covering the influences of microbiome, parasites, related theories and others, this review focuses on recent advances in the hygiene hypothesis field. In addition, the main immunological mechanisms underlying the hygiene hypothesis are also discussed. We also strongly encourage that researchers do not consider the hygiene hypothesis as a theory based strictly on hygiene habits, but a theory combining diverse influences, as illustrated in this review as the hygiene hypothesis net.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available