Journal
ACTA TROPICA
Volume 125, Issue 2, Pages 123-127Publisher
ELSEVIER
DOI: 10.1016/j.actatropica.2012.10.012
Keywords
Anopheles gambiae s.l.; L1014F and L1014S; kdr; Insecticide resistance; Malaria; Burkina Faso
Categories
Funding
- CORUS project [6015]
- National Malaria Control Program/Ministry of Health of Burkina Faso
- BBSRC [BBS/E/C/00005193] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/C/00005193] Funding Source: researchfish
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We investigated the occurrence of the L1014F and L1014S kdr mutations in malaria vector populations in Burkina Faso (West Africa). A cross-sectional survey was conducted at 10 sites all located in cotton cultivation areas which are assumed to be the major insecticide resistance selection foci in Burkina Faso. The hot ligation method was used to detect the two kdr mutations in field collected Anopheles gambiae s.l. samples. For the first time in Burkina Faso the L1014S mutation was identified in both M and S forms of An. gambiae s.s. populations collected from the site of Koupela in the central-eastern region at low frequency. Furthermore, the L1014S mutation was also found in one specimen of An. arabiensis collected from the Dano site. The data generated in this study provides additional evidence of the spread of the L1014S mutation into An. gambiae s.l. populations in West Africa. It is now important to evaluate the role of the L1014S mutation in the pyrethroid resistance phenotype and assess its potential impact on the efficacy of pyrethroid-based control measures in West Africa where several resistance mutations now coexist. (c) 2012 Published by Elsevier B.V.
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