Journal
ACTA TROPICA
Volume 121, Issue 2, Pages 152-155Publisher
ELSEVIER
DOI: 10.1016/j.actatropica.2011.10.009
Keywords
Plasmodium vivax; HLA-DRB1; Antibody response
Categories
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Sao Paulo State, Brazil [02/09546-1, 06/09546-1]
- Conselho Nacional para o Desenvolvimento Cientifico e Tecnologico (CNPq), Brasilia, Brazil [302353/03-8, 410405/2006-0]
- COLCIENCIAS [1106-04-16489)]
- Ministry of Social Protection [2304-04-19524, 253-2005]
- National Institute of Allergy and Infectious Diseases (NIAID) [49486/TMRC]
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We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HILA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the H1A-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria. (C) 2011 Elsevier B.V. All rights reserved.
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