Journal
ACTA TROPICA
Volume 120, Issue -, Pages S158-S168Publisher
ELSEVIER
DOI: 10.1016/j.actatropica.2010.07.006
Keywords
Opisthorchiasis; Opisthorchis; Clonorchis; Cholangiocarcinoma; Liver fluke; Liver cancer; Food-borne trematodiases; Anthelmintic; Praziquantel; Hepatobiliary disease
Categories
Funding
- National Institute of Allergy and Infectious Disease [UO1AI065871]
Ask authors/readers for more resources
Liver fluke infection caused by Opisthorchis viverrini is a major public health problem in Thailand and the Lao People's Democratic Republic (Lao PDR: Laos). Currently, more than 600 million people are at risk of infection with these fish-borne trematodes and/or their close relatives. Opisthorchiasis has been studied extensively in Thailand, where about 8 million people are infected with the liver fluke. Here we review the pathogenesis, control and re-emergence of O. viverrini infection, in particular in Thailand and, to a lesser extent in Lao PDR given the contiguous geographical range of O. viverrini through these two regions. We also review the association of O. viverrini infection and cholangiocarcinoma, bile duct cancer, and highlight new findings on pathogenesis of liver fluke-induced cholangiocarcinogenesis. Last, we comment on national control strategies in Thailand for the control of O. viverrini infection aimed at reduction in the prevalence of O. viverrini-associated liver cancer in the longer term. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available