Journal
ACTA TROPICA
Volume 119, Issue 1, Pages 61-65Publisher
ELSEVIER
DOI: 10.1016/j.actatropica.2011.04.009
Keywords
Chagas disease; DTU; Trypanosoma cruzi; Transmission cycles; Cytb; Maximum likelihood
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Funding
- European Union [223034]
- faculty of sciences from the Universidad de los Andes
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Chagas disease caused by Trypanosoma cruzi comprises an important problem of public health in the Americas. This parasite has been recently divided into six Discrete Typing Units (DTUs) due to its high genetic diversity. We sequenced the Cytochorme b (Cytb) gene of 70 T. cruzi I Colombian clones finding four genotypes related to transmission cycles of Chagas disease in Colombia and also to specific hosts of T. cruzi. The genotypes herein described based on Cytb gene sequences are in accordance with those found using the mini-exon gene and reveals once again the enormous genetic diversity at sub-DTU level evidenced in T. cruzi I. (C) 2011 Elsevier B.V. All rights reserved.
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