Journal
ACTA TROPICA
Volume 115, Issue 1-2, Pages 69-76Publisher
ELSEVIER
DOI: 10.1016/j.actatropica.2009.12.007
Keywords
Larvicidal activity; Angiostrongylus cantonensis; Ginger; Anthelmintic activity; DPPH and peroxyl radical
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Funding
- National Science Council, Taiwan [NSC-95-2320-B-037-052-MY2]
- Kaohsiung Medical University Research Foundation [Q096008, Q097029]
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In this study, we investigated the anthelmintic activity of [6]-gingerol, [10]-shogaol, [10]-gingerol, [6]-shogaol and hexahydrocurcumin, a constituent isolate from the roots of ginger (Zingiber officinale), for the parasite Angiostrongylus cantonensis. This study found that the above constituents killed A. cantonensis larvae or reduced their spontaneous movements in a time- and dose-dependent manner. The larvicidal effect or ability to halt spontaneous parasite movement of [10]-shogaol, [6]-gingerol, [10]-gingerol, [6]-shogaol and hexahydrocurcumin at various concentrations was reached from 24 to 72 h, respectively. Further investigation to determine minimal effective doses of [10]-gingerol and hexahydrocurcumin revealed [10]-gingerol to have a greater maximum larvicidal effect and loss of spontaneous movements than hexahydrocurcumin, mebendazole and albendazole. These constituents of ginger showed effects against DPPH and peroxyl radical under larvicidal effect. Together, these findings suggest that these constituents of ginger might be used as larvicidal agents against A. cantonensis. (C) 2010 Elsevier B.V. All rights reserved.
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