Journal
ACTA TROPICA
Volume 112, Issue 2, Pages 231-235Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.actatropica.2009.07.018
Keywords
Filaria; Onchocerca; Prostaglandin E-2; TGF-beta; Macrophages; Immunoregulation
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Prostaglandins generated by multiple tissue and immune cells exhibit regulatory effects on the vascular and immune systems. Prostaglandin E-2 (PGE(2)), in particular, affects innate as well as adaptive immune mechanisms. We identified PGE(2) in host immune cells adjacent to Onchocerca volvulus in subcutaneous onchocercomas and the affected skin. Using immunohistology, PGE(2) was predominantly detected in infiltrating macrophages but also in plasma cells. Consecutive sections revealed concomitant presence of PGE(2) and transforming growth factor-beta (TGF-beta), representing a second immunoregulative mediator in macrophages and plasma cells. TGF-beta was preferentially observed in the infiltrating macrophages in patients with a generalized hyporeactive onchocerciasis and less in patients with the hyperreactive form. The presence of PGE(2) and TGF-beta in adjoining host cells infiltrating in the onchocercoma and dermis may indicate containment of inflammatory responses that could favour survival of the filarial parasite. (C) 2009 Elsevier B.V. All rights reserved.
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