Journal
ACTA RADIOLOGICA
Volume 52, Issue 3, Pages 336-339Publisher
ROYAL SOC MEDICINE PRESS LTD
DOI: 10.1258/ar.2010.100355
Keywords
CNS; MR imaging; brain/brainstem; adults
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Creutzfeldt-Jakob disease is a rare and fatal neurodegenerative disorder with MR findings predominantly limited to the grey matter of the cortex and the basal ganglia. Sporadic Creutzfeldt-Jakob disease can produce a spectrum of MR imaging findings of the brain, most notably on DWI and FLAIR sequences. Involvement of the basal ganglia and neocortex is the most common finding, but isolated involvement of the cortex can also be seen. We describe the clinical history and MRI findings of three patients with sporadic Creutzfeldt-Jakob disease confirmed by brain biopsy or autopsy and review the literature of imaging manifestations of this disease.
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