Journal
ACTA RADIOLOGICA
Volume 51, Issue 8, Pages 910-923Publisher
SAGE PUBLICATIONS LTD
DOI: 10.3109/02841851.2010.502126
Keywords
Model studies; paramagnetic agents; magnetization transfer; target image
Funding
- National Institutes of Health (NIH) [EB004582, 5R01EB004582-03]
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In this review we describe the status of development for a new class of magnetic resonance (MR) contrast agents, based on chemical exchange saturation transfer (CEST). The mathematics and physics relevant to the description of the CEST effect in MR are presented in an appendix published in the online version only. We discuss the issues arising when translating in vitro results obtained with CEST agents to using these MR agents in in vivo model studies and in humans. Examples are given on how these agents are imaged in vivo. We summarize the status of development of these CEST agents, and speculate about the next steps that may be taken towards the demonstration of CEST MR imaging in clinical applications.
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